ATF3 transcription factor and its emerging roles in immunity and cancer

被引：352

作者：

Thompson, Matthew R. ^{[1
]}

Xu, Dakang ^{[1
]}

Williams, Bryan R. G. ^{[1
]}

机构：

[1] Monash Univ, Monash Inst Med Res, Melbourne, Vic 3004, Australia

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2009年 / 87卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ATF3; Transcriptional regulation; Immunity; TLRs; Oncogenesis; Gene expression; STRESS-INDUCIBLE GENE; BETA-CELL APOPTOSIS; PROSTATE-CANCER; NEGATIVE REGULATOR; EPITHELIAL-CELLS; UP-REGULATION; GADD153; GENE; EXPRESSION; BINDING; TUMORIGENESIS;

D O I：

10.1007/s00109-009-0520-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Advances made in understanding the immunobiology of Toll-like receptors have recently generated new momentum for the study of ATF3 in immunity. Moreover, the role of ATF3 in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.

引用

页码：1053 / 1060

页数：8

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