Mutation in Bovine β-Carotene Oxygenase 2 Affects Milk Color

被引：80

作者：

Berry, S. D. ^{[1
]}

Davis, S. R. ^{[1
]}

Beattie, E. M. ^{[1
]}

Thomas, N. L. ^{[1
]}

Burrett, A. K. ^{[1
]}

Ward, H. E. ^{[1
]}

Stanfield, A. M. ^{[1
]}

Biswas, M. ^{[1
]}

Ankersmit-Udy, A. E. ^{[1
]}

Oxley, P. E. ^{[1
]}

Barnett, J. L. ^{[1
]}

Pearson, J. F. ^{[1
]}

van der Does, Y. ^{[2
]}

MacGibbon, A. H. F. ^{[2
]}

Spelman, R. J. ^{[3
]}

Lehnert, K. ^{[1
]}

Snell, R. G. ^{[1
]}

机构：

[1] ViaLactia Biosci, Auckland 1149, New Zealand

[2] Fonterra Res Ctr, Palmerston North 4442, New Zealand

[3] Livestock Improvement Corp, Hamilton 3240, New Zealand

来源：

GENETICS | 2009年 / 182卷 / 03期

关键词：

VITAMIN-A; IN-VIVO; CLEAVAGE; IDENTIFICATION; ENZYME; QTL; YIELD; GENE;

D O I：

10.1534/genetics.109.101741

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

beta-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk beta-carotene and subsequently identified a premature stop codon in bovine beta-carotene oxygenase 2 (BCO2), which also affects serum beta-carotene content. The BCO2 enzyme is thereby identified as a key regulator of P-carotene metabolism.

引用

页码：923 / 926

页数：4

共 19 条

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