The importance of plasma concentration in addition apolipoprotein E to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe

被引：73

作者：

Haddy, N

De Bacquer, D

Chemaly, MM

Maurice, M

Ehnholm, C

Evans, A

Sans, S

Martins, MD

De Backer, G

Siest, G

Visvikis, S

机构：

[1] INSERM, U525 Equipe 4, F-54000 Nancy, France

[2] State Univ Ghent, Dept Publ Hlth, Ghent, Belgium

[3] Natl Inst Publ Hlth, Dept Biochem, Helsinki, Finland

[4] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Belfast, Antrim, North Ireland

[5] Inst Natl Saude, Program Cronicat, Lisbon, Portugal

[6] Inst Natl Saude, Unidade Quim Clin, Lisbon, Portugal

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2002年 / 10卷 / 12期

关键词：

cardiovascular risk; ApoEurope; apoE polymorphism; apoE concentration; inter-individual lipid levels variation;

D O I：

10.1038/sj.ejhg.5200864

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interindividual variation in the concentration of plasma lipids which are associated with coronary artery disease (CAD) risk is determined by a combination of genetic and environmental factors. This study investigates the effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: Finland, France, Northern Ireland, Portugal, and Spain. Age and sex significantly influenced serum cholesterol, TG and apoE concentrations. The age effect differs in males and females. The allele frequencies of the apoE gene, one of the most widely studied CAD susceptibility genes, were determined: the epsilon2 allele frequency and the apoE concentration showed a north-south increasing gradient while the epsilon4 allele frequency showed the reverse. ApoE plays an important role in lipid metabolism. Total cholesterol and TG concentrations were significantly dependent on apoE genotype in both sexes. These differences in lipids between genotypes were more pronounced when plasma apoE concentrations were taken into account.

引用

页码：841 / 850

页数：10

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