Expression of SHV-2 β-lactamase and of reduced amounts of OmpK36 porin in Klebsiella pneumoniae results in increased resistance to cephalosporins and carbapenems

被引：64

作者：

Crowley, B

Benedí, VJ

Doménech-Sánchez, A

机构：

[1] UIB, CSIC, IMEDEA, Microbiol Lab, Palma de Mallorca 07071, Spain

[2] Univ Hosp Aintree, Publ Hlth Lab, Liverpool L9 7AL, Merseyside, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 11期

关键词：

D O I：

10.1128/AAC.46.11.3679-3682.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A Klebsiella pneumoniae clinical isolate was resistant to cefoxitin, cefotaxime, ceftazidime, ceftazidime-clavulanate, piperacillin-tazobactam (MICs, >256 mug/ml in all cases), and meropenem (MIC, 16 mug/ml) and was intermediate to imipenem (MIC, 8 mug/ml). Decreased expression of the OmpK36 porin and expression of an SHV-2 beta-lactamase contributed to the observed resistance to these beta-lactam-containing agents.

引用

页码：3679 / 3682

页数：4

共 13 条

[11] Detection of genes coding for extended-spectrum SHV beta-lactamases in clinical isolates by a molecular genetic method, and comparison with the E test [J].