Organocatalytic Enantioselective Cross-Aldol Reactions of Aldehydes with Isatins: Formation of Two Contiguous Quaternary Centered 3-Substituted 3-Hydroxyindol-2-ones

被引：79

作者：

Xue, Fei ^{[1
]}

Zhang, Shilei ^{[1
]}

Liu, Lu ^{[1
]}

Duan, Wenhu ^{[1
]}

Wang, Wei ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2009年 / 4卷 / 11期

关键词：

aldehydes; aldol; isatins; organocatalysis; CATALYTIC ASYMMETRIC ALDOL; HIGHLY EFFICIENT CATALYST; NATURAL-PRODUCTS; CARBON CENTERS; KETONES; PROLINE; MICHAEL; (R)-CONVOLUTAMYDINE; STEREOCENTERS; CONSTRUCTION;

D O I：

10.1002/asia.200900243

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Good neighbors: Cross-aldol reactions of isatins with aldehydes, catalyzed by (S)-pyrrolidine tetrazole are developed. In the process, two contiguous quaternary centers and one chiral carbon are created simultaneously with good efficiency. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1664 / 1667

页数：4

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