Mechanisms of Disease: Telomere Diseases.

被引：624

作者：

Calado, Rodrigo T. ^{[1
]}

Young, Neal S. ^{[1
]}

机构：

[1] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 361卷 / 24期

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; DOMINANT DYSKERATOSIS-CONGENITA; BONE-MARROW-TRANSPLANTATION; HEMATOPOIETIC STEM-CELLS; GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; ACUTE MYELOID-LEUKEMIA; APLASTIC-ANEMIA; MYELODYSPLASTIC SYNDROMES; CHROMOSOMAL INSTABILITY;

D O I：

10.1056/NEJMra0903373

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The Nobel Prize in Physiology or Medicine 2009 was recently awarded to three scientists for their work on telomeres, which are repetitive DNA structures at the tips of chromosomes, and the enzyme telomerase. Telo meres protect the genome from loss of genetic material. This review recounts the medical implications of telomeres and focuses on a group of diseases in which the loss of telomeres appears to be causal. Copyright © 2009 Massachusetts Medical Society.

引用

页码：2353 / 2365

页数：13

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