Mechanical Stress Regulates Bone Metabolism Through MicroRNAs

被引：98

作者：

Yuan, Yu ^{[1
,2
,3
]}

Zhang, Lingli ^{[1
]}

Tong, Xiaoyang ^{[1
]}

Zhang, Miao ^{[1
]}

Zhao, Yilong ^{[1
]}

Guo, Jianming ^{[1
]}

Lei, Le ^{[1
]}

Chen, Xi ^{[1
,4
]}

Tickner, Jennifer ^{[2
,3
]}

Xu, Jiake ^{[1
,2
,3
]}

Zou, Jun ^{[1
]}

机构：

[1] Shanghai Univ Sport, Sch Kinesiol, 339 Changhai Rd, Shanghai 200438, Peoples R China

[2] Univ Western Australia, Sch Pathol, Perth, WA 6009, Australia

[3] Univ Western Australia, Lab Med, Perth, WA 6009, Australia

[4] Wenzhou Med Univ, Sch Sports Sci, Wenzhou, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2017年 / 232卷 / 06期

基金：

英国医学研究理事会; 中国国家自然科学基金;

关键词：

MESENCHYMAL STEM-CELLS; INDUCED OSTEOGENIC DIFFERENTIATION; OSTEOBLAST DIFFERENTIATION; OSTEOCLAST DIFFERENTIATION; MECHANOSENSITIVE MICRORNA; EXPRESSION PROFILE; MC3T3-E1; CELLS; RAW264.7; STRETCH; EXERCISE;

D O I：

10.1002/jcp.25688

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

There are many lines of evidence indicating that mechanical stress regulates bone metabolism and promotes bone growth. BMP, Wnt, ERK1/2, and OPG/RANKL are the main molecules thought to regulate the effects of mechanical loading on bone formation. Recently, microRNAs were found to be involved in bone cell proliferation and differentiation, regulating the balance of bone formation and bone resorption. Emerging evidence indicates that microRNAs also participate in mechanical stress-mediated bone metabolism, and is associated with disuse induced osteoporosis or osteopenia. Mechanical stress is able to induce expression of microRNAs that modulate the expression of osteogenic and bone resorption factors, leading to the positive impact of mechanical stress on bone. This review discusses the emerging evidence implicating an important role for microRNAs in the mechanical stress response in bone cells, as well as the challenges of translating microRNA research into potential treatment. (C) 2016 Wiley Periodicals, Inc.

引用

页码：1239 / 1245

页数：7

共 69 条

[11]

MicroRNA-218, microRNA-191*, microRNA-3070a and microRNA-33 are responsive to mechanical strain exerted on osteoblastic cells [J].