Stability of the 6-carbanion of uracil analogues:: Mechanistic implications for model reactions of orotidine-5′-monophosphate decarboxylase

被引：19

作者：

Wong, Freeman M. ^{[1
]}

Capule, Christina C. ^{[1
]}

Wu, Weiming ^{[1
]}

机构：

[1] San Francisco State Univ, Dept Chem & Biochem, San Francisco, CA 94132 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 26期

关键词：

D O I：

10.1021/ol0624981

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The pK(a)'s of the 6- CH groups of N- methyl- 2- pyridone and N- methyl- 4- pyridone in aqueous solution were determined. No correlation between the stability of the carbanions and the rate of decarboxylation of the corresponding carboxylic acids was found.

引用

页码：6019 / 6022

页数：4

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