Rare genetic mutations shed light on the pathogenesis of Parkinson disease

被引:166
作者
Dawson, TM
Dawson, VL
机构
[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21287 USA
[4] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21287 USA
关键词
D O I
10.1172/JCI200317575
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:145 / 151
页数:7
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共 69 条
[1]   Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].
Abeliovich, A ;
Schmitz, Y ;
Fariñas, I ;
Choi-Lundberg, D ;
Ho, WH ;
Castillo, PE ;
Shinsky, N ;
Verdugo, JMG ;
Armanini, M ;
Ryan, A ;
Hynes, M ;
Phillips, H ;
Sulzer, D ;
Rosenthal, A .
NEURON, 2000, 25 (01) :239-252
[2]   Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease [J].
Auluck, PK ;
Chan, HYE ;
Trojanowski, JQ ;
Lee, VMY ;
Bonini, NM .
SCIENCE, 2002, 295 (5556) :865-868
[3]   The septin CDCrel-1 binds syntaxin and inhibits exocytosis [J].
Beites, CL ;
Xie, H ;
Bowser, R ;
Trimble, WS .
NATURE NEUROSCIENCE, 1999, 2 (05) :434-439
[4]   Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism [J].
Bonifati, V ;
Rizzu, P ;
van Baren, MJ ;
Schaap, O ;
Breedveld, GJ ;
Krieger, E ;
Dekker, MCJ ;
Squitieri, F ;
Ibanez, P ;
Joosse, M ;
van Dongen, JW ;
Vanacore, N ;
van Swieten, JC ;
Brice, A ;
Meco, G ;
van Duijn, CM ;
Oostra, BA ;
Heutink, P .
SCIENCE, 2003, 299 (5604) :256-259
[5]   The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders [J].
Chung, KKK ;
Dawson, VL ;
Dawson, TM .
TRENDS IN NEUROSCIENCES, 2001, 24 (11) :S7-S14
[6]   Parkin ubiquitinates the α-synuclein-interacting protein, synphilin-1:: implications for Lewy-body formation in Parkinson disease [J].
Chung, KKK ;
Zhang, Y ;
Lim, KL ;
Tanaka, Y ;
Huang, H ;
Gao, J ;
Ross, CA ;
Dawson, VL ;
Dawson, TM .
NATURE MEDICINE, 2001, 7 (10) :1144-1150
[7]   The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease [J].
Clayton, DF ;
George, JM .
TRENDS IN NEUROSCIENCES, 1998, 21 (06) :249-254
[8]   Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct [J].
Conway, KA ;
Rochet, JC ;
Bieganski, RM ;
Lansbury, PT .
SCIENCE, 2001, 294 (5545) :1346-1349
[9]   New animal models for Parkinson's disease [J].
Dawson, TM .
CELL, 2000, 101 (02) :115-118
[10]   Animal models of PD: Pieces of the same puzzle? [J].
Dawson, TM ;
Mandir, AS ;
Lee, MK .
NEURON, 2002, 35 (02) :219-222