Activation of gene expression by small RNA

被引：197

作者：

Froehlich, Kathrin S. ^{[1
]}

Vogel, Joerg ^{[1
]}

机构：

[1] Max Planck Inst Infect Biol, RNA Biol Grp, D-10117 Berlin, Germany

来源：

CURRENT OPINION IN MICROBIOLOGY | 2009年 / 12卷 / 06期

关键词：

SMALL REGULATORY RNA; STAPHYLOCOCCUS-AUREUS RNAIII; ESCHERICHIA-COLI; MESSENGER-RNA; NONCODING RNAS; SOLUBLE-RNA; DSRA RNA; DISCOORDINATE EXPRESSION; TRANSLATIONAL INITIATION; SALMONELLA-TYPHIMURIUM;

D O I：

10.1016/j.mib.2009.09.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Small regulatory RNAs (sRNAs) commonly act to downregulate gene expression. In bacteria, however, sRNAs have also been shown to activate genes by a variety of direct or indirect mechanisms. Several sRNAs (DsrA, GImZ, RNAIII, RprA, RyhB, and Qrr) act as direct translational activators by an 'antiantisense mechanism' in the 5' mRNA region to liberate a sequestered ribosome binding site, while pairing of GadY sRNA to the 3'-end alters processing and increases stability of its target mRNA. Indirect activation includes cases of RNA mimicry in which degradation of the activating GImZ sRNA is suppressed by the highly similar GImY sRNA, or where a pseudo-target mRNA traps MicM sRNA to derepress porin synthesis.

引用

页码：674 / 682

页数：9

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