Potential of immunomodulatory host defense peptides as novel anti-infectives

被引：199

作者：

Easton, Donna M. ^{[1
]}

Nijnik, Anastasia ^{[1
]}

Mayer, Matthew L. ^{[1
,2
]}

Hancock, Robert E. W. ^{[1
]}

机构：

[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Fac Med, Woodward Instruct Resource Ctr, Vancouver, BC V6T 1Z4, Canada

来源：

TRENDS IN BIOTECHNOLOGY | 2009年 / 27卷 / 10期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

INNATE IMMUNITY; ANTIMICROBIAL PEPTIDES; DENDRITIC CELLS; GROWTH-FACTOR; CATHELICIDIN LL-37; IN-VITRO; CPG-ODN; RECEPTOR; VACCINE; RESPONSES;

D O I：

10.1016/j.tibtech.2009.07.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation. Antimicrobial host defense peptides have been investigated for their potential as a new class of antimicrobial drugs. Recently their immunomodulatory activities have begun to be appreciated. Modulation of innate immunity by synthetic variants of host defense peptides, called innate defense regulators (IDRs), is protective without direct antimicrobial action. We discuss the potential and current limitations in exploiting the immunomodulatory activity of IDRs as a novel anti-infective pathway. IDRs show significant promise and current research is uncovering mechanistic information that will aid in the future development of IDRs for clinical use.

引用

页码：582 / 590

页数：9

共 81 条

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