Antioxidant and antidermatophytic activities of essential oil and extracts of Magnolia liliflora Desr.

This study was carried out to assess the antioxidant and antidermatophytic activities of the essential oil and extracts of Magnolia liliflora Desr. Antioxidant activity was evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The free radical scavenging activities of the oil and ethyl acetate extract were found to be superior (IC50 values = 10.11 and 16.17 mu g/ml, respectively) as compared to butylatedhydre-oxyanisole (BHA), (IC50 value = 18.27 mu g/ml). Also the ethyl acetate extract revealed the highest phenolic contents (96.13 mg/g of dry wt) as compared to the other extracts. Further, the oil (1000 mu g/disc) and extracts (1500 mu g/disc) revealed 42.36-63.12% and 19.07-54.14% antidermatophytic effect, respectively along with their respective MIC values ranging from 62.5 to 500 and 250 to 2000 mu g/ml against the members of Trichophyton and Microsporum spp. Also the oil had strong detrimental effect on spore germination of tested fungal pathogens as well as concentration and time dependent kinetic inhibition of Microsporum canis KCTC 6348. The results of this study justify a potential role of M. liliflora to serve as a natural antioxidant and antidermatophytic agent. (C) 2009 Elsevier Ltd. All rights reserved.