3,4-dihydropyrimidin-2(1H)-ones: Fast synthesis under microwave irradiation in solvent free conditions

被引：77

作者：

Stefani, HA ^{[1
]}

Gatti, PM ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, Brazil

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 12期

关键词：

D O I：

10.1080/00397910008087395

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave irradiation has been used to accelerate the synthesis of the Biginelli compounds, in one-pot reaction between P-keto esters, aryl aldehydes, and urea. These solvent-free reactions show that it is possible to prepare these compounds in a short time reaction and with good yield and easily isolable.

引用

页码：2165 / 2173

页数：9

共 15 条

[1]

ATWAL KS, 1987, HETEROCYCLES, V26, P1189

[2] DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .3. 3-CARBAMOYL-4-ARYL-1,2,3,4-TETRAHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS ORALLY EFFECTIVE ANTIHYPERTENSIVE AGENTS [J].

ATWAL, KS ;

SWANSON, BN ;

UNGER, SE ;

FLOYD, DM ;

MORELAND, S ;

HEDBERG, A ;

OREILLY, BC .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :806-811

[3] DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .2. 3-SUBSTITUTED-4-ARYL-1,4-DIHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS POTENT MIMICS OF DIHYDROPYRIDINES [J].

ATWAL, KS ;

ROVNYAK, GC ;

KIMBALL, SD ;

FLOYD, DM ;

MORELAND, S ;

SWANSON, BN ;

GOUGOUTAS, JZ ;

SCHWARTZ, J ;

SMILLIE, KM ;

MALLEY, MF .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (09) :2629-2635

[4] SUBSTITUTED 1,4-DIHYDROPYRIMIDINES .3. SYNTHESIS OF SELECTIVELY FUNCTIONALIZED 2-HETERO-1,4-DIHYDROPYRIMIDINES [J].

ATWAL, KS ;

ROVNYAK, GC ;

OREILLY, BC ;

SCHWARTZ, J .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (25) :5898-5907

[5] SIMPLE AND REGIOSELECTIVE SYNTHESIS OF N-SUBSTITUTED PYRIMIDINE-2(1H)-ONES AND PYRIMIDINE-2(1H)-THIONES [J].

BARLUENGA, J ;

TOMAS, M ;

RUBIO, V ;

GOTOR, V .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (16) :675-676

[6] 1,4-CYCLOADDITION OF 1,3-DIAZABUTADIENES WITH ENAMINES - AN EFFICIENT ROUTE TO THE PYRIMIDINE RING [J].

BARLUENGA, J ;

TOMAS, M ;

BALLESTEROS, A ;

LOPEZ, LA .

TETRAHEDRON LETTERS, 1989, 30 (34) :4573-4576

[7]

Biginelli P., 1893, GAZZ CHIM ITAL, V23, P360

[8]

BROWN DJ, 1962, PYRIMIDINES, P440

[9] MICROWAVE-ASSISTED ORGANIC-REACTIONS [J].

CADDICK, S .

TETRAHEDRON, 1995, 51 (38) :10403-10432

[10] THE USE OF MICROWAVE-OVENS FOR RAPID ORGANIC-SYNTHESIS [J].

GEDYE, R ;

SMITH, F ;

WESTAWAY, K ;

ALI, H ;

BALDISERA, L ;

LABERGE, L ;

ROUSELL, J .

TETRAHEDRON LETTERS, 1986, 27 (03) :279-282

← 1 2 →