UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species

被引：71

作者：

Agatsuma, T

Akama, T

Nara, S

Matsumiya, S

Nakai, R

Ogawa, H

Otaki, S

Ikeda, S

Saitoh, Y

Kanda, Y

机构：

[1] Kyowa Hakka Kogyo Co Ltd, Tokyo Res Labs, Machida, Tokyo 1948533, Japan

[2] Kyowa Hakko Kogyo Co Ltd, Shizuoka 4118731, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 25期

关键词：

D O I：

10.1021/ol026923b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures and stereochemistry were elucidated by a combination of two-dimensional NMR and X-ray crystallographic analysis. UCS1025A showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and anti proliferative activity against human tumor cell lines.

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页码：4387 / 4390

页数：4

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