Biosynthetic studies of the tetramic acid antibiotic trichosetin

被引：28

作者：

Marfori, EC ^{[1
]}

Bamba, T ^{[1
]}

Kajiyama, S ^{[1
]}

Fukusaki, E ^{[1
]}

Kobayashi, A ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Suita, Osaka 5650871, Japan

来源：

TETRAHEDRON | 2002年 / 58卷 / 33期

关键词：

dual culture; Catharanthus roseus; Trichoderma harzianum; trichosetin; tetramic acid; polyketide; biosynthesis;

D O I：

10.1016/S0040-4020(02)00689-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A feeding experiment with C-13-labeled precursors was conducted in the dual cultures of Trichoderma harzianum H14 and Catharanthus roseus callus to determine the biosynthetic origin of the carbon atoms in trichosetin. Results showed that trichosetin originated from two separate biogenetic units. One unit is an octaketide intermediate directly derived from eight intact acetate units joined in a head-to-tail fashion of a polyketide pathway. The other unit is serine. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6655 / 6658

页数：4

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