Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake

被引:54
作者
Clegg, DJ
Air, EL
Benoit, SC
Sakai, RS
Seeley, RJ
Woods, SC
机构
[1] Univ Cincinnati, Med Ctr, Dept Psychiat, Cincinnati, OH 45267 USA
[2] Univ Cincinnati, Med Ctr, Dept Biomed Sci, Cincinnati, OH 45267 USA
[3] Univ Cincinnati, Med Ctr, Dept Cell Biol Neurobiol & Anat, Cincinnati, OH 45267 USA
关键词
agouti-related protein; orexin-A; lateral hypothalamus;
D O I
10.1152/ajpregu.00399.2002
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The lateral hypothalamus (LH) has a critical role in the control of feeding and drinking. Melanin-concentrating hormone (MCH) is an orexigenic peptidergic neurotransmitter produced primarily in the LH, and agouti-related protein (AgRP) is an orexigenic peptidergic neurotransmitter produced exclusively in the arcuate (ARC), an area that innervates the LH. We assessed drinking and eating after third ventricular (i3vt) administration of MCH and AgRP. MCH (2.5, 5, and 10 mug i3vt) significantly increased food as well as water intake over 4 h when administered during either the light or the dark portion of the day-night cycle. When MCH (5 mug) was administered to rats with access to water but no food, they drank significantly more water than when given the vehicle. AgRP (7 mug i3vt), on the other hand, increased water intake but only in proportion to food intake during the dark and the light, and water intake was not increased after i3vt AgRP in the absence of food. Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake.
引用
收藏
页码:R494 / R499
页数:6
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