New Onto-Tools: Promoter-Express, nsSNPCounter and Onto-Translate

被引:15
作者
Khatri, Purvesh
Desai, Valmik
Tarca, Adi L.
Sellamuthu, Sivakumar
Wildman, Derek E.
Romero, Roberto
Draghici, Sorin
机构
[1] Wayne State Univ, Dept Comp Sci, Detroit, MI 48202 USA
[2] NICHD, Perinatol Res Branch, NIH, Detroit, MI 48201 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1093/nar/gkl213
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
The Onto- Tools suite is composed of an annotation database and eight complementary, web- accessible data mining tools: Onto- Express, Onto- Compare, Onto- Design, Onto- Translate, Onto- Miner, PathwayExpress, Promoter- Express and nsSNPCounter. Promoter- Express is a new tool added to the Onto- Toolsensemble that facilitates the identification of transcription factor binding sites active in specific conditions. nsSNPCounter is another new tool that allows computation and analysis of synonymous and non- synonymous codon substitutions for studying evolutionary rates of protein coding genes. Onto- Translate has also been enhanced to expand its scope and accuracy by fully utilizing the capabilities of the Onto- Tools database. Currently, Onto- Translate allows arbitrary mappings between 28 types of IDs for 53 organisms. Onto- Tools are freely available at http://vortex.cs.wayne.edu/Projects.html.
引用
收藏
页码:W626 / W631
页数:6
相关论文
共 35 条
[1]
Ashburner M, 2001, GENOME RES, V11, P1425
[2]
ASHBURNER M, NATURE GENETICS, V25, P25
[3]
The universal protein resource (UniProt) [J].
Bairoch, A ;
Apweiler, R ;
Wu, CH ;
Barker, WC ;
Boeckmann, B ;
Ferro, S ;
Gasteiger, E ;
Huang, HZ ;
Lopez, R ;
Magrane, M ;
Martin, MJ ;
Natale, DA ;
O'Donovan, C ;
Redaschi, N ;
Yeh, LSL .
NUCLEIC ACIDS RESEARCH, 2005, 33 :D154-D159
[4]
Benson Dennis A, 2005, Nucleic Acids Res, V33, pD34
[5]
The Protein Data Bank [J].
Berman, HM ;
Westbrook, J ;
Feng, Z ;
Gilliland, G ;
Bhat, TN ;
Weissig, H ;
Shindyalov, IN ;
Bourne, PE .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242
[6]
The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003 [J].
Boeckmann, B ;
Bairoch, A ;
Apweiler, R ;
Blatter, MC ;
Estreicher, A ;
Gasteiger, E ;
Martin, MJ ;
Michoud, K ;
O'Donovan, C ;
Phan, I ;
Pilbout, S ;
Schneider, M .
NUCLEIC ACIDS RESEARCH, 2003, 31 (01) :365-370
[7]
DBEST - DATABASE FOR EXPRESSED SEQUENCE TAGS [J].
BOGUSKI, MS ;
LOWE, TMJ ;
TOLSTOSHEV, CM .
NATURE GENETICS, 1993, 4 (04) :332-333
[8]
MatchMiner: a tool for batch navigation among gene and gene product identifiers [J].
Bussey, KJ ;
Kane, D ;
Sunshine, M ;
Narasimhan, S ;
Nishizuka, S ;
Reinhold, WC ;
Zeeberg, B ;
Ajay ;
Weinstein, JN .
GENOME BIOLOGY, 2003, 4 (04)
[9]
Natural selection on protein-coding genes in the human genome [J].
Bustamante, CD ;
Fledel-Alon, A ;
Williamson, S ;
Nielsen, R ;
Hubisz, MT ;
Glanowski, S ;
Tanenbaum, DM ;
White, TJ ;
Sninsky, JJ ;
Hernandez, RD ;
Civello, D ;
Adams, MD ;
Cargill, M ;
Clark, AG .
NATURE, 2005, 437 (7062) :1153-1157
[10]
Characterization of single-nucleotide polymorphisms in coding regions of human genes [J].
Cargill, M ;
Altshuler, D ;
Ireland, J ;
Sklar, P ;
Ardlie, K ;
Patil, N ;
Lane, CR ;
Lim, EP ;
Kalyanaraman, N ;
Nemesh, J ;
Ziaugra, L ;
Friedland, L ;
Rolfe, A ;
Warrington, J ;
Lipshutz, R ;
Daley, GQ ;
Lander, ES .
NATURE GENETICS, 1999, 22 (03) :231-238