Locomotor and learning deficits in adult rats exposed to monosodium-L-glutamate during early life

被引:39
作者
Ali, MM
Bawari, M
Misra, UK
Babu, GN
机构
[1] Ind Toxicol Res Ctr, Neurotoxicol Sect, Lucknow 226001, Uttar Pradesh, India
[2] Sanjay Gandhi Postgrad Inst Med Sci, Dept Neurol, Lucknow 226014, Uttar Pradesh, India
关键词
monosodium-L-glutamate; subneuroxic dose; locomotor activity; learning; rat;
D O I
10.1016/S0304-3940(00)00958-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neonatal administration of neurotoxic doses of monosodium-L-glutamate (MSG) to rats causes neuronal necrosis of the hypothalamus along with behavioral abnormalities. In the present study the behavioral effects in rats treated with subneurotoxic doses of MSG (2 mg/g, p.o.,for 10 days) at the weaned stage were investigated at day 90 post-dosing. The MSG-treated rats did not show significant changes in any of the components of spontaneous locomotor activity but, after apomorphine challenge, marked decreases in the distance travelled, ambulatory and stereotypic times, and the number of stereotypic movements with an increase in the resting time were observed. Significant decrease in the active avoidance learning performance was observed in the MSG-treated rats in the learning (acquisition) phase without any changes in the extinction and relearning phases. The results indicate that exposure to MSG in early life in rats could lead to subtle behavioral aberrations in late adulthood. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码:57 / 60
页数:4
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