Mutation induction by high-density, 50-Hz magnetic fields in human MeWo cells exposed in the DNA synthesis phase

被引：38

作者：

Miyakoshi, J ^{[1
]}

Kitagawa, K ^{[1
]}

Takebe, H ^{[1
]}

机构：

[1] KANSAI MED UNIV, DEPT PHARMACOL, MORIGUCHI, OSAKA 570, JAPAN

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1997年 / 71卷 / 01期

关键词：

D O I：

10.1080/095530097144445

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Exposure of cultured human MeWo cells to high-density (400 mT at 50 Hz) extremely low frequency magnetic fields (ELF-MF) induced mutations in the hypoxanthine-guanine phosphoribosyl transferase gene. Mutation induced by the ELF-ME increased during the DNA-synthesis phase in synchronously growing cells. DNA replication errors and/or disturbance of the mismatch repair systems caused by exposure to ELF-MF may be involved in the mutagenic effect.

引用

页码：75 / 79

页数：5

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