共 19 条
Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment
被引:65
作者:

de Leon, MJ
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Segal, S
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Tarshish, CY
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

DeSanti, S
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Zinkowski, R
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Mehta, PD
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Convit, A
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Caraos, C
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Rusinek, H
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Tsui, W
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Saint Louis, LA
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

DeBernardis, J
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Kerkman, D
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Qadri, F
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Gary, A
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Lesbre, P
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

Wisniewski, T
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA

论文数: 引用数:
h-index:
机构:

Davies, P
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA
机构:
[1] NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA
[2] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
[3] Mol Geriatr Corp, Vernon Hills, IL USA
[4] New York State Off Mental Retardat & Dev Disabil, Inst Basic Res, Staten Isl, NY USA
[5] McGill Univ, Douglas Hosp, Montreal, PQ, Canada
[6] Albert Einstein Coll Med, Bronx, NY 10467 USA
关键词:
cerebrospinal fluid;
Alzheimer disease;
mild cognitive impairment;
magnetic resonance imaging;
tau;
amyloid beta;
longitudinal;
D O I:
10.1016/S0304-3940(02)01038-8
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Cross-sectional cerebrospinal fluid (CSF) levels of tau and amyloid (A) beta (beta) are of diagnostic importance for Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, most longitudinal studies of tau fail to demonstrate progression. Because predominantly brain-derived proteins such as tau, have higher ventricle to lumbar ratios, we hypothesized that adjusting for the ventricular enlargement of AD would correct for the dilution of tau, and improve detection of longitudinal change. Abeta which is not exclusively brain derived, shows a ratio <1, and no benefit was expected from adjustment. In a 1 year longitudinal study of eight MCI and ten controls, we examined CSF levels of hyperphosphorylated (P) tau231, Aβ40, and Aβ42. In cross-section, MCI patients showed elevated Ptau231 and Aβ40 levels, and greater ventricular volumes. Longitudinally, only after adjusting for the ventricular volume and only for Ptau231, were increases seen in MCI. Further studies are warranted on mechanisms of tau clearance and on using imaging to interpret CSF studies. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:183 / 186
页数:4
相关论文
共 19 条
[1]
Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample
[J].
Andreasen, N
;
Minthon, L
;
Clarberg, A
;
Davidsson, P
;
Gottfries, J
;
Vanmechelen, E
;
Vanderstichele, H
;
Winblad, B
;
Blennow, K
.
NEUROLOGY,
1999, 53 (07)
:1488-1494

Andreasen, N
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Minthon, L
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Clarberg, A
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Davidsson, P
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Gottfries, J
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Vanmechelen, E
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Vanderstichele, H
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Winblad, B
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Blennow, K
论文数: 0 引用数: 0
h-index: 0
机构: Piteae River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden
[2]
CSF phosphorylated tau protein and mild cognitive impairment: a prospective study
[J].
Arai, H
;
Ishiguro, K
;
Ohno, H
;
Moriyama, M
;
Itoh, N
;
Okamura, N
;
Matsui, T
;
Morikawa, Y
;
Horikawa, E
;
Kohno, H
;
Sasaki, H
;
Imahori, K
.
EXPERIMENTAL NEUROLOGY,
2000, 166 (01)
:201-203

Arai, H
论文数: 0 引用数: 0
h-index: 0
机构:
Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Ishiguro, K
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Ohno, H
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Moriyama, M
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Itoh, N
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Okamura, N
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Matsui, T
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Morikawa, Y
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Horikawa, E
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Kohno, H
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Sasaki, H
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan

Imahori, K
论文数: 0 引用数: 0
h-index: 0
机构: Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan
[3]
Effect of genetic risk factors and disease progression on the cerebrospinal fluid tau levels in Alzheimer's disease
[J].
Arai, H
;
Terajima, M
;
Miura, M
;
Higuchi, S
;
Muramatsu, T
;
Matsushita, S
;
Machida, N
;
Nakagawa, T
;
Lee, VMY
;
Trojanowski, JQ
;
Sasaki, H
.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY,
1997, 45 (10)
:1228-1231

Arai, H
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Terajima, M
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Miura, M
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Higuchi, S
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Muramatsu, T
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Matsushita, S
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Machida, N
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Nakagawa, T
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Lee, VMY
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Trojanowski, JQ
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN

Sasaki, H
论文数: 0 引用数: 0
h-index: 0
机构: MITSUBISHI KAGAKU BIOCLIN LABS,DEPT RES & DEV,TOKYO,JAPAN
[4]
Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow-up
[J].
Blomberg, M
;
Jensen, M
;
Basun, H
;
Lannfelt, L
;
Wahlund, LO
.
NEUROSCIENCE LETTERS,
1996, 214 (2-3)
:163-166

Blomberg, M
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Institute, Dept. of Clin. Neurosci. and Fam. M., Huddinge University Hospital

Jensen, M
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Institute, Dept. of Clin. Neurosci. and Fam. M., Huddinge University Hospital

Basun, H
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Institute, Dept. of Clin. Neurosci. and Fam. M., Huddinge University Hospital

Lannfelt, L
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Institute, Dept. of Clin. Neurosci. and Fam. M., Huddinge University Hospital

Wahlund, LO
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Institute, Dept. of Clin. Neurosci. and Fam. M., Huddinge University Hospital
[5]
CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects
[J].
Buerger, K
;
Teipel, SJ
;
Zinkowski, R
;
Blennow, K
;
Arai, H
;
Engel, R
;
Hofmann-Kiefer, K
;
McCulloch, C
;
Ptok, U
;
Heun, R
;
Andreasen, N
;
DeBernardis, J
;
Kerkman, D
;
Moeller, HJ
;
Davies, P
;
Hampel, H
.
NEUROLOGY,
2002, 59 (04)
:627-629

Buerger, K
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Teipel, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Zinkowski, R
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Blennow, K
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Arai, H
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Engel, R
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Hofmann-Kiefer, K
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

McCulloch, C
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Ptok, U
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Heun, R
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Andreasen, N
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

DeBernardis, J
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Kerkman, D
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Moeller, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Davies, P
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA

Hampel, H
论文数: 0 引用数: 0
h-index: 0
机构: Mol Geriatr Corp, Vernon Hills, IL 60061 USA
[6]
MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN
[J].
FOLSTEIN, MF
;
FOLSTEIN, SE
;
MCHUGH, PR
.
JOURNAL OF PSYCHIATRIC RESEARCH,
1975, 12 (03)
:189-198

FOLSTEIN, MF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,MED SCH,DEPT PSYCHIAT,PORTLAND,OR 97201

FOLSTEIN, SE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,MED SCH,DEPT PSYCHIAT,PORTLAND,OR 97201

MCHUGH, PR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,MED SCH,DEPT PSYCHIAT,PORTLAND,OR 97201
[7]
Brain atrophy progression measured from registered serial MRI: Validation and application to Alzheimer's disease
[J].
Fox, NC
;
Freeborough, PA
.
JOURNAL OF MAGNETIC RESONANCE IMAGING,
1997, 7 (06)
:1069-1075

Fox, NC
论文数: 0 引用数: 0
h-index: 0
机构:
UCL Natl Hosp Neurol & Neurosurg, Dementia Res Grp, London WC1N 3BG, England UCL Natl Hosp Neurol & Neurosurg, Dementia Res Grp, London WC1N 3BG, England

Freeborough, PA
论文数: 0 引用数: 0
h-index: 0
机构:
UCL Natl Hosp Neurol & Neurosurg, Dementia Res Grp, London WC1N 3BG, England UCL Natl Hosp Neurol & Neurosurg, Dementia Res Grp, London WC1N 3BG, England
[8]
Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231
[J].
Hampel, H
;
Buerger, K
;
Kohnken, R
;
Teipel, SJ
;
Zinkowski, R
;
Moeller, HJ
;
Rapoport, SI
;
Davies, P
.
ANNALS OF NEUROLOGY,
2001, 49 (04)
:545-546

Hampel, H
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Psychiat, D-8000 Munich, Germany Univ Munich, Dept Psychiat, D-8000 Munich, Germany

Buerger, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Dept Psychiat, D-8000 Munich, Germany

Kohnken, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Dept Psychiat, D-8000 Munich, Germany

Teipel, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Dept Psychiat, D-8000 Munich, Germany

Zinkowski, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Dept Psychiat, D-8000 Munich, Germany

Moeller, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Dept Psychiat, D-8000 Munich, Germany

Rapoport, SI
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Dept Psychiat, D-8000 Munich, Germany

Davies, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Dept Psychiat, D-8000 Munich, Germany
[9]
Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease
[J].
Kanai, M
;
Shizuka, M
;
Urakami, K
;
Matsubara, E
;
Harigaya, Y
;
Okamoto, K
;
Shoji, M
.
NEUROSCIENCE LETTERS,
1999, 267 (01)
:65-68

Kanai, M
论文数: 0 引用数: 0
h-index: 0
机构: Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

Shizuka, M
论文数: 0 引用数: 0
h-index: 0
机构: Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

Urakami, K
论文数: 0 引用数: 0
h-index: 0
机构: Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

Matsubara, E
论文数: 0 引用数: 0
h-index: 0
机构: Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

Harigaya, Y
论文数: 0 引用数: 0
h-index: 0
机构: Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

Okamoto, K
论文数: 0 引用数: 0
h-index: 0
机构: Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan

Shoji, M
论文数: 0 引用数: 0
h-index: 0
机构: Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan
[10]
Neuropsychological prediction of decline to dementia in nondemented elderly
[J].
Kluger, A
;
Ferris, SH
;
Golomb, J
;
Mittelman, MS
;
Reisberg, B
.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,
1999, 12 (04)
:168-179

Kluger, A
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, William & Sylvia Silberstein Aging & Dementia Res, Dept Psychiat, New York, NY 10016 USA

Ferris, SH
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, William & Sylvia Silberstein Aging & Dementia Res, Dept Psychiat, New York, NY 10016 USA

Golomb, J
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, William & Sylvia Silberstein Aging & Dementia Res, Dept Psychiat, New York, NY 10016 USA

Mittelman, MS
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, William & Sylvia Silberstein Aging & Dementia Res, Dept Psychiat, New York, NY 10016 USA

Reisberg, B
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, William & Sylvia Silberstein Aging & Dementia Res, Dept Psychiat, New York, NY 10016 USA