Control of simian immunodeficiency virus SIVmac239 is not predicted by inheritance of Mamu-B*17-containing haplotypes

被引：38

作者：

Wojcechowskyi, Jason A.

Yant, Levi J.

Wiseman, Roger W.

O'Connor, Shelby L.

O'Connor, David H.

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53715 USA

[2] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 01期

关键词：

D O I：

10.1128/JVI.01636-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It is well established that host genetics, especially major histocompatibillity complex (MHC) genes, are important determinants of human immunodeficiency virus disease progression. Studies with simian immunodeficiency virus (SIV)-infected Indian rhesus macaques have associated Mamu-B*17 with control of virus replication. Using microsatellite haplotyping of the 5-Mb MHC region, we compared disease progression among SIVmac239-infected Indian rhesus macaques that possess Mamu-B*17-containing MHC haplotypes that are identical by descent. We discovered that SIV-infected animals possessing identical Mamu-B*17containing haplotypes had widely divergent disease courses. Our results demonstrate that the inheritance of a particular Mamu-B*17-containing haplotype is not sufficient to predict SIV disease outcome.

引用

页码：406 / 410

页数：5

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