Synthesis of five nevirapine metabolites

被引：20

作者：

Grozinger, KG ^{[1
]}

Byrne, DP ^{[1
]}

Nummy, LJ ^{[1
]}

Ridges, MD ^{[1
]}

Salvagno, A ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Ctr Res & Dev, Dept Chem Dev, Ridgefield, CT 06877 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2000年 / 37卷 / 02期

关键词：

D O I：

10.1002/jhet.5570370203

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nevirapine (1) is a non-nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune(R) since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This paper describes the syntheses of these metabolites.

引用

页码：229 / 239

页数：11

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