A novel silver(I)-mediated DNA base pair

被引：139

作者：

Zimmermann, N ^{[1
]}

Meggers, E ^{[1
]}

Schultz, PG ^{[1
]}

机构：

[1] The Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 46期

关键词：

D O I：

10.1021/ja0279951

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have generated a novel silver(I)-mediated unnatural DNA base pair consisting of two 2,6-bis(ethylthiomethyl)pyridine nucleobases SPy. This metallo-base pair has a remarkably high pairing stability and selectivity which rivals that of the natural base pairs dA:dT and dC:dG. UV-melting experiments revealed that the dSPy:dSPy self-pair can replace natural base pairs at multiple sites and still form stable DNA duplexes. Copyright © 2002 American Chemical Society.

引用

页码：13684 / 13685

页数：2

共 23 条

[1] HALOGENOTRICARBONYLRHENIUM(I) COMPLEXES OF 2,6-BIS-(THIOALKYL)-PYRIDINES AND 2,6-BIS-(THIOARYL)-PYRIDINES, THEIR SYNTHESES AND SOLUTION STEREODYNAMICS [J].

ABEL, EW ;

ELLIS, D ;

ORRELL, KG .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1992, (14) :2243-2249

[2] Structure of a copper-mediated base pair in DNA [J].

Atwell, S ;

Meggers, E ;

Spraggon, G ;

Schultz, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (49) :12364-12367

[3] Stability and selectivity of unnatural DNA with five-membered-ring nucleobase analogues [J].

Berger, M ;

Luzzi, SD ;

Henry, AA ;

Romesberg, FE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (07) :1222-1226

[4]

Berger M, 2000, ANGEW CHEM INT EDIT, V39, P2940, DOI 10.1002/1521-3773(20000818)39:16<2940::AID-ANIE2940>3.0.CO

[5]

2-#

[6]

BERGER M, 2000, ANGEW CHEM, V112, P3069

[7] HSAB PRINCIPLE [J].

CHATTARAJ, PK ;

LEE, H ;

PARR, RG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (05) :1855-1856

[8]

COTTON FA, 1999, ADV INORG CHEM, P1084

[9] RECOGNITION BY VIRAL AND CELLULAR DNA-POLYMERASES OF NUCLEOSIDES BEARING BASES WITH NONSTANDARD HYDROGEN-BONDING PATTERNS [J].

HORLACHER, J ;

HOTTIGER, M ;

PODUST, VN ;

HUBSCHER, U ;

BENNER, SA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6329-6333

[10]

Kool ET, 1998, BIOPOLYMERS, V48, P3, DOI 10.1002/(SICI)1097-0282(1998)48:1<3::AID-BIP2>3.0.CO

← 1 2 3 →