Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease

被引：456

作者：

Agusti, Alvar ^{[1
,2
,3
]}

Hogg, James C. ^{[4
]}

机构：

[1] Inst Invest Agusti Pi i Sunyer, Resp Inst, Hosp Clin, Barcelona, Spain

[2] Univ Barcelona, Barcelona, Spain

[3] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp, Madrid, Spain

[4] Univ British Columbia, St Pauls Hosp, Ctr Heart & Lung Innovat, Vancouver, BC, Canada

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2019年 / 381卷 / 13期

关键词：

SMALL-AIRWAY OBSTRUCTION; LUNG-FUNCTION; NATURAL-HISTORY; DNA METHYLATION; GLOBAL STRATEGY; EMPHYSEMA; SMOKERS; INFLAMMATION; COPD; HYPERTENSION;

D O I：

10.1056/NEJMra1900475

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

A pair of review articles examines our current understanding of the biology, diagnosis, and treatment of chronic obstructive pulmonary disease. This article focuses on the pathogenesis of COPD.

引用

页码：1248 / 1256

页数：9

共 73 条

[21]

Abnormal Lung Aging in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis [J].

Faner, Rosa ;

Rojas, Mauricio ;

MacNee, William ;

Agusti, Alvar .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (04) :306-313

[22]

NATURAL-HISTORY OF CHRONIC AIR-FLOW OBSTRUCTION [J].

FLETCHER, C ;

PETO, R .

BMJ-BRITISH MEDICAL JOURNAL, 1977, 1 (6077) :1645-1648

[23]

Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease [J].

Ghosh, Moumita ;

Miller, York E. ;

Nakachi, Ichiro ;

Kwon, Jennifer B. ;

Baron, Anna E. ;

Brantley, Alexandra E. ;

Merrick, Daniel T. ;

Franklin, Wilbur A. ;

Keith, Robert L. ;

Vandivier, R. William .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197 (07) :885-896

[24]

Differences in systemic inflammation between cigarette and biomass smoke-induced COPD [J].

Golpe, Rafael ;

Martin-Robles, Irene ;

Sanjuan-Lopez, Pilar ;

Perez-de-Llano, Luis ;

Gonzalez-Juanatey, Carlos ;

Lopez-Campos, Jose L. ;

Arellano-Orden, Elena .

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2017, 12 :2639-2646

[25]

Gulia KK, 2005, PROCEEDINGS OF THE 2ND INTERIM CONGRESS OF THE WORLD FEDERATION OF SLEEP RESEARCH AND SLEEP MEDICINE SOCIETIES, P7

[26]

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis [J].

Hobbs, Brian D. ;

de Jong, Kim ;

Lamontagne, Maxime ;

Bosse, Yohan ;

Shrine, Nick ;

Artigas, Maria Soler ;

Wain, Louise V. ;

Hall, Ian P. ;

Jackson, Victoria E. ;

Wyss, Annah B. ;

London, Stephanie J. ;

North, Kari E. ;

Franceschini, Nora ;

Strachan, David P. ;

Beaty, Terri H. ;

Hokanson, John E. ;

Crapo, James D. ;

Castaldi, Peter J. ;

Chase, Robert P. ;

Bartz, Traci M. ;

Heckbert, Susan R. ;

Psaty, Bruce M. ;

Gharib, Sina A. ;

Zanen, Pieter ;

Lammers, Jan W. ;

Oudkerk, Matthijs ;

Groen, H. J. ;

Locantore, Nicholas ;

Tal-Singer, Ruth ;

Rennard, Stephen I. ;

Vestbo, Jurgen ;

Timens, Wim ;

Pare, Peter D. ;

Latourelle, Jeanne C. ;

Dupuis, Josee ;

O'Connor, George T. ;

Wilk, Jemma B. ;

Kim, Woo Jin ;

Lee, Mi Kyeong ;

Oh, Yeon-Mok ;

Vonk, Judith M. ;

de Koning, Harry J. ;

Leng, Shuguang ;

Belinsky, Steven A. ;

Tesfaigzi, Yohannes ;

Manichaikul, Ani ;

Wang, Xin-Qun ;

Rich, Stephen S. ;

Barr, R. Graham ;

Sparrow, David .

NATURE GENETICS, 2017, 49 (03) :426-432

[27]

The nature of small-airway obstruction in chronic obstructive pulmonary disease [J].

Hogg, JC ;

Chu, F ;

Utokaparch, S ;

Woods, R ;

Elliott, WM ;

Buzatu, L ;

Cherniack, RM ;

Rogers, RM ;

Sciurba, FC ;

Coxson, HO ;

Paré, PD .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (26) :2645-2653

[28]

Pathophysiology of airflow limitation in chronic obstructive pulmonary disease [J].

Hogg, JC .

LANCET, 2004, 364 (9435) :709-721

[29]

mTOR pathway activation drives lung cell senescence and emphysema [J].

Houssaini, Amal ;

Breau, Marielle ;

Kebe, Kanny ;

Abid, Shariq ;

Marcos, Elisabeth ;

Lipskaia, Larissa ;

Rideau, Dominique ;

Parpaleix, Aurelien ;

Huang, Jin ;

Amsellem, Valerie ;

Vienney, Nora ;

Validire, Pierre ;

Maitre, Bernard ;

Attwe, Aya ;

Lukas, Christina ;

Vindrieux, David ;

Boczkowski, Jorge ;

Derumeaux, Genevieve ;

Pende, Mario ;

Bernard, David ;

Meiners, Silke ;

Adnot, Serge .

JCI INSIGHT, 2018, 3 (03)

[30]

Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease. [J].

Hurst, John R. ;

Vestbo, Jorgen ;

Anzueto, Antonio ;

Locantore, Nicholas ;

Muellerova, Hana ;

Tal-Singer, Ruth ;

Miller, Bruce ;

Lomas, David A. ;

Agusti, Alvar ;

MacNee, William ;

Calverley, Peter ;

Rennard, Stephen ;

Wouters, Emiel F. M. ;

Wedzicha, Jadwiga A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (12) :1128-1138

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