Homeostatic Immunity and the Microbiota

被引：983

作者：

Belkaid, Yasmine ^{[1
,2
]}

Harrison, Oliver J. ^{[1
]}

机构：

[1] NIAID, Mucosal Immunol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[2] NIAID, Microbiome Program, NIH, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2017年 / 46卷 / 04期

关键词：

REGULATORY T-CELLS; ARYL-HYDROCARBON RECEPTOR; INNATE LYMPHOID-CELLS; SEGMENTED FILAMENTOUS BACTERIA; GERM-FREE-MICE; CD103(+)CD11B(+) DENDRITIC CELLS; LECTIN REGIII-GAMMA; CHAIN FATTY-ACIDS; GUT MICROBIOTA; COMMENSAL BACTERIA;

D O I：

10.1016/j.immuni.2017.04.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The microbiota plays a fundamental role in the induction, education, and function of the host immune system. In return, the host immune system has evolved multiple means by which to maintain its symbiotic relationship with the microbiota. The maintenance of this dialogue allows the induction of protective responses to pathogens and the utilization of regulatory pathways involved in the sustained tolerance to innocuous antigens. The ability of microbes to set the immunological tone of tissues, both locally and systemically, requires tonic sensing of microbes and complex feedback loops between innate and adaptive components of the immune system. Here we review the dominant cellular mediators of these interactions and discuss emerging themes associated with our current understanding of the homeostatic immunological dialogue between the host and its microbiota.

引用

页码：562 / 576

页数：15

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