Telomere maintenance as a target for anticancer drug discovery

被引：576

作者：

Neidle, S ^{[1
]}

Parkinson, G ^{[1
]}

机构：

[1] Inst Canc Res, Chester Beatty Labs, CRC, Biomol Struct Unit, London SW3 6JB, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 05期

关键词：

D O I：

10.1038/nrd793

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Maintenance of telomeres - specialized complexes that protect the ends of chromosomes is undertaken by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells that have been examined so far, but is absent in most normal cells. So, targeting telomere-maintenance mechanisms could potentially halt tumour growth across a broad spectrum of tumour types, with little cytotoxic effect outside tumours. Here, we describe the current understanding of telomere biology, and the application of this knowledge to the development of anticancer drugs.

引用

页码：383 / 393

页数：11

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