Exercise Enhances Hippocampal-Dependent Learning in the Rat: Evidence for a BDNF-Related Mechanism

被引：139

作者：

Griffin, Eadaoin W.

Bechara, Ranya G.

Birch, Amy M.

Kelly, Aine M. ^{[1
]}

机构：

[1] Univ Dublin, Trinity Coll, Sch Med, Dept Physiol, Dublin 2, Ireland

来源：

HIPPOCAMPUS | 2009年 / 19卷 / 10期

关键词：

learning; DG; BDNF; exercise; perirhinal cortex; LONG-TERM POTENTIATION; NEUROTROPHIC FACTOR; RECOGNITION MEMORY; SPATIAL MEMORY; MESSENGER-RNA; ENVIRONMENTAL ENRICHMENT; PERIRHINAL CORTEX; INCREASES; NEUROGENESIS; EXPRESSION;

D O I：

10.1002/hipo.20631

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spatial) and object substitution (nonspatial) learning. These behavioral changes were accompanied by increased expression of BDNF protein in the dentate gyrus, hippocampus, and perirhinal cortex. The effects of exercise on object substitution were mimicked by intracerebroventricular injection of BDNF protein. These data are consistent with the hypothesis that exercise has the potential to enhance cognitive function in young healthy rats, possibly via a mechanism involving increased BDNF expression in specific brain regions. (C) 2009 Wiley-Liss, Inc.

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页码：973 / 980

页数：8

相关论文

共 34 条

[1]

The exercise-induced expression of BDNF within the hippocampus varies across life-span [J].

Adlard, PA ;

Perreau, VM ;

Cotman, CW .

NEUROBIOLOGY OF AGING, 2005, 26 (04) :511-520

[2]

Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor [J].

Aicardi, G ;

Argilli, E ;

Cappello, S ;

Santi, S ;

Riccio, M ;

Thoenen, H ;

Canossa, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15788-15792

[3]

Mild forced treadmill exercise enhances spatial learning in the aged rat [J].

Albeck, DS ;

Sano, K ;

Prewitt, GE ;

Dalton, L .

BEHAVIOURAL BRAIN RESEARCH, 2006, 168 (02) :345-348

[4]

Exercise influences spatial learning in the radial arm maze [J].

Anderson, BJ ;

Rapp, DN ;

Baek, DH ;

McCloskey, DP ;

Coburn-Litvak, PS ;

Robinson, JK .

PHYSIOLOGY & BEHAVIOR, 2000, 70 (05) :425-429

[5]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[6]

Spatial memory, recognition memory, and the hippocampus [J].

Broadbent, NJ ;

Squire, LR ;

Clark, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (40) :14515-14520

[7]

The role of the perirhinal cortex and hippocampus in learning, memory, and perception [J].

Buckley, MJ .

QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 2005, 58 (3-4) :246-268

[8]

Recognition memory in the rat is associated with increased BDNF release and ERK activation in the dentate gyrus [J].

Callaghan, C. ;

Loscher, C. ;

Kelly, A. .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2006, 16 :S58-S58

[9]

Treadmill exercise enhances passive avoidance learning in rats: The role of down-regulated serotonin system in the limbic system [J].

Chen, Hsiun-Ing ;

Lin, Li-Chun ;

Yu, Lung ;

Liu, Yu-Fan ;

Kuo, Yu-Min ;

Huang, A-Min ;

Chuang, Jih-Ing ;

Wu, Fong-Sen ;

Liao, Pao-Chi ;

Jen, Chauying J. .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2008, 89 (04) :489-496

[10]

Voluntary exercise rescues deficits in spatial memory and long-term potentiation in prenatal ethanol-exposed male rats [J].

Christie, BR ;

Swann, SE ;

Fox, CJ ;

Froc, D ;

Lieblich, SE ;

Redila, V ;

Webber, A .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (06) :1719-1726

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