RHO-GTPases and cancer

被引：1178

作者：

Sahai, E ^{[1
]}

Marshall, CJ ^{[1
]}

机构：

[1] Inst Canc Res, London SW3 6JB, England

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 02期

关键词：

D O I：

10.1038/nrc725

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDR This is then exchanged for GTP and the cycle is repeated. The switching between these two states regulates a wide range of cellular processes. A branch of the RAS family - the RHO proteins - is also involved in cancer, but what is the role of these proteins and would they make good therapeutic targets?

引用

页码：133 / +

页数：11

共 143 条

[1] Motility-related proteins as markers for head and neck squamous cell cancer
Abraham, MT
Kuriakose, MA
Sacks, PG
Yee, H
Chiriboga, L
Bearer, EL
Delacure, MD
[J]. LARYNGOSCOPE, 2001, 111 (07) : 1285 - 1289
[2] Adamson P, 1999, J IMMUNOL, V162, P2964
[3] p21WAF1/CIP1 is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor β- and Sp1-responsive element:: Involvement of the small GTPase RhoA
Adnane, J
Bizouarn, FA
Qian, YM
Hamilton, AD
Sebti, SM
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (12) : 6962 - 6970
[4] High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential
Akisawa, N
Nishimori, I
Iwamura, T
Onishi, S
Hollingsworth, MA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (02) : 395 - 400
[5] TRANSFORMING P21(RAS) MUTANTS AND C-ETS-2 ACTIVATE THE CYCLIN D1 PROMOTER THROUGH DISTINGUISHABLE REGIONS
ALBANESE, C
JOHNSON, J
WATANABE, G
EKLUND, N
VU, D
ARNOLD, A
PESTELL, RG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (40) : 23589 - 23597
[6] Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton
Aronheim, A
Broder, YC
Cohen, A
Fritsch, A
Belisle, B
Abo, A
[J]. CURRENT BIOLOGY, 1998, 8 (20) : 1125 - 1128
[7] Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression
Assoian, RK
Schwartz, MA
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (01) : 48 - 53
[8] Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster
Baron, M
O'Leary, V
Evans, DAP
Hicks, M
Hudson, K
[J]. MOLECULAR AND GENERAL GENETICS, 2000, 264 (1-2): : 98 - 104
[9] The AP-1 site and MMP gene regulation: What is all the fuss about?
Benbow, U
Brinckerhoff, CE
[J]. MATRIX BIOLOGY, 1997, 15 (8-9) : 519 - 526
[10] Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
Bhowmick, NA
Ghiassi, M
Bakin, A
Aakre, M
Lundquist, CA
Engel, ME
Arteaga, CL
Moses, HL
[J]. MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (01) : 27 - 36

← 1 2 3 4 5 6 7 8 9 10 →