RHO-GTPases and cancer

被引：1178

作者：

Sahai, E ^{[1
]}

Marshall, CJ ^{[1
]}

机构：

[1] Inst Canc Res, London SW3 6JB, England

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 02期

关键词：

D O I：

10.1038/nrc725

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDR This is then exchanged for GTP and the cycle is repeated. The switching between these two states regulates a wide range of cellular processes. A branch of the RAS family - the RHO proteins - is also involved in cancer, but what is the role of these proteins and would they make good therapeutic targets?

引用

页码：133 / +

页数：11

共 143 条

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