Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD)

被引：134

作者：

Arjamaa, Olli ^{[2
]}

Nikinmaa, Mikko ^{[2
]}

Salminen, Antero ^{[3
,4
]}

Kaarniranta, Kai ^{[1
,5
]}

机构：

[1] Univ Kuopio, Dept Ophthalmol, Inst Clin Med, FIN-70211 Kuopio, Finland

[2] Univ Turku, Dept Biol, Ctr Excellence Evolutionary Genet & Physiol, FIN-20014 Turku, Finland

[3] Univ Kuopio, Inst Clin Med, Dept Neurol, FIN-70211 Kuopio, Finland

[4] Kuopio Univ Hosp, Dept Neurol, FIN-70211 Kuopio, Finland

[5] Kuopio Univ Hosp, Dept Ophthalmol, FIN-70211 Kuopio, Finland

来源：

AGEING RESEARCH REVIEWS | 2009年 / 8卷 / 04期

基金：

芬兰科学院;

关键词：

AMD; Hypoxia; Inflammation; Oxidative stress; HYPOXIA-INDUCIBLE FACTOR; COMPLEMENT-FACTOR-H; RETINAL-PIGMENT EPITHELIUM; HSP90 MOLECULAR CHAPERONE; FACTOR-KAPPA-B; OXIDATIVE STRESS; INNATE IMMUNITY; FACTOR; 1-ALPHA; NADPH OXIDASE; RISK-FACTORS;

D O I：

10.1016/j.arr.2009.06.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the elderly throughout the world. AMD is attributed to a complex interaction of genetic and environmental factors. It is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium (RPE), and Bruch's membrane, as well as alterations in choroidal capillaries. Aging and age-associated degenerative diseases, such as AMD, are intimately associated with decreased levels of tissue oxygenation and hypoxia that may induce accumulation of detrimental RPE-associated deposits, inflammation and neovascularization processes in retina. Hypoxia-inducible factor (HIF) is the master regulator for hypoxia-induced cellular adaptation that is involved in NF-kappa B signaling and the autophagic protein clearance system. In this review, we discuss role of HIF in AMD pathology and as a possible therapeutic target. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：349 / 358

页数：10

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