Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step

被引：97

作者：

Fang, Yuan-Qing ^{[1
]}

Karisch, Robert ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Chem Labs, Toronto, ON M5S 3H6, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 04期

关键词：

D O I：

10.1021/jo062228w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] A family of four potent KDR kinase inhibitors containing an indol-2-yl quinolin-2-one structure was utilizing a Pd-catalyzed tandem C-N and C-C coupling sequence.

引用

页码：1341 / 1346

页数：6

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