Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: Selective targeting of gyrase or topoisomerase IV by quinolones

被引：191

作者：

Pan, XS ^{[1
]}

Fisher, LM ^{[1
]}

机构：

[1] UNIV LONDON ST GEORGES HOSP,SCH MED,DEPT CELLULAR & MOL SCI,MOL GENET GRP,LONDON SW17 0RE,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 02期

关键词：

D O I：

10.1128/AAC.41.2.471

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

gyrA and parC mutations have been identified in Streptococcus pneumoniae mutants stepwise selected for resistance to sparfloxacin, an antipneumococcal fluoroquinolone. GyrA mutations (at the position equivalent to resistance hot spot Ser-83 in Escherichia coli GyrA) were found in all 17 first-step mutants examined and preceded DNA topoisomerase IV ParC mutations (at Ser-79 or Glu-83), which appeared only in second-step mutants. The targeting of gyrase by sparfloxacin in S. pneumoniae but of topoisomerase IV by ciprofloxacin indicates that target preference can be altered by changes in quinolone structure.

引用

页码：471 / 474

页数：4

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