MicroRNAs Potentiate Neural Development

被引：306

作者：

Fineberg, Sarah K. ^{[1
,4
]}

Kosik, Kenneth S. ^{[5
]}

Davidson, Beverly L. ^{[1
,2
,3
]}

机构：

[1] Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[3] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA

[4] Univ Iowa, Med Scientist Training Program, Iowa City, IA 52242 USA

[5] Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA

来源：

NEURON | 2009年 / 64卷 / 03期

关键词：

NEURONAL DIFFERENTIATION; REGULATED MICRORNA; EXPRESSION; BRAIN; SURVIVAL; PATHWAY; CORTEX; REST; GENE; DYSREGULATION;

D O I：

10.1016/j.neuron.2009.10.020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs that regulate mRNA expression. In vertebrates, more distinct miRNAs are expressed in the brain than in any other tissue, where they are hypothesized to function in neural development. Recent reports describing the effects of specific miRNAs during development, and studies employing miRNA depletion as neural commitment proceeds in the embryo, support a requisite role for miRNAs in cell-fate decisions and provide clues to their function in other aspects of nervous system development.

引用

页码：303 / 309

页数：7

共 63 条

[1] Sequence variants in SLITRK1 are associated with Tourette's syndrome [J].

Abelson, JF ;

Kwan, KY ;

O'Roak, BJ ;

Baek, DY ;

Stillman, AA ;

Morgan, TM ;

Mathews, CA ;

Pauls, DA ;

Rasin, MR ;

Gunel, M ;

Davis, NR ;

Ercan-Sencicek, AG ;

Guez, DH ;

Spertus, JA ;

Leckman, JF ;

Dure, LS ;

Kurlan, R ;

Singer, HS ;

Gilbert, DL ;

Farhi, A ;

Louvi, A ;

Lifton, RP ;

Sestan, N ;

State, MW .

SCIENCE, 2005, 310 (5746) :317-320

[2] Heterogeneous dysregulation of microRNAs across the autism spectrum [J].

Abu-Elneel, Kawther ;

Liu, Tsunglin ;

Gazzaniga, Francesca S. ;

Nishimura, Yuhei ;

Wall, Dennis P. ;

Geschwind, Daniel H. ;

Lao, Kaiqin ;

Kosik, Kenneth S. .

NEUROGENETICS, 2008, 9 (03) :153-161

[3] The many faces of REST oversee epigenetic programming of neuronal genes [J].

Ballas, N ;

Mandel, G .

CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (05) :500-506

[4] Mammalian mirtron genes [J].

Berezikov, Eugene ;

Chung, Wei-Jen ;

Willis, Jason ;

Cuppen, Edwin ;

Lai, Eric C. .

MOLECULAR CELL, 2007, 28 (02) :328-336

[5] Dysregulation of miRNA 181b in the temporal cortex in schizophrenia [J].

Beveridge, Natalie J. ;

Tooney, Paul A. ;

Carroll, Adam P. ;

Gardiner, Erin ;

Bowden, Nikola ;

Scott, Rodney J. ;

Tran, Nham ;

Dedova, Irina ;

Cairns, Murray J. .

HUMAN MOLECULAR GENETICS, 2008, 17 (08) :1156-1168

[6] Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation [J].

Beveridge, Natalie J. ;

Tooney, Paul A. ;

Carroll, Adam P. ;

Tran, Nham ;

Cairns, Murray J. .

CELLULAR SIGNALLING, 2009, 21 (12) :1837-1845

[7] Adenosine deamination in human transcripts generates novel microRNA binding sites [J].

Borchert, Glen M. ;

Gilmore, Brian L. ;

Spengler, Ryan M. ;

Xing, Yi ;

Lanier, William ;

Bhattacharya, Debashish ;

Davidson, Beverly L. .

HUMAN MOLECULAR GENETICS, 2009, 18 (24) :4801-4807

[8] bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].

Brennecke, J ;

Hipfner, DR ;

Stark, A ;

Russell, RB ;

Cohen, SM .

CELL, 2003, 113 (01) :25-36

[9] Strand selective generation of endo-siRNAs from the Na/phosphate transporter gene Slc34a1 in murine tissues [J].

Carlile, Mark ;

Swan, Daniel ;

Jackson, Kelly ;

Preston-Fayers, Keziah ;

Ballester, Benoit ;

Flicek, Paul ;

Werner, Andreas .

NUCLEIC ACIDS RESEARCH, 2009, 37 (07) :2274-2282

[10] Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization [J].

Cavaillé, J ;

Buiting, K ;

Kiefmann, M ;

Lalande, M ;

Brannan, CI ;

Horsthemke, B ;

Bachellerie, JP ;

Brosius, J ;

Hüttenhofer, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) :14311-14316

← 1 2 3 4 5 6 7 →