Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis

被引：88

作者：

McGiffert, C

Contos, JJA

Friedman, B

Chun, J

机构：

[1] Univ Calif San Diego, Sch Med, Grad Program Neurosci, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

FEBS LETTERS | 2002年 / 531卷 / 01期

关键词：

CD34; PECAM-1; EDG; G-protein coupled receptor; cerebral cortex; mesencephalon; LPA; S1P; 1pB;

D O I：

10.1016/S0014-5793(02)03404-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a comparison of embryonic brain expression patterns of lysophosphatidic acid and sphingosine 1-phosphate receptor genes (lpa(1-3) and s1p(1-5), respectively), transcripts detected by Northern blot were subsequently localized using in situ hybridization. We found striking s1p(1) expression adjacent to several ventricles. Near the lateral ventricle, s1p(1) expression was temporally and spatially coincident with neurogenesis and overlapped with lpa(1) in the neocortical area. We also observed a widespread diffuse pattern for lpa(2-3) and a scattered punctate pattern for s1p(1-3). The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p(1) influences neurogenesis and s1p(1-3) influence angiogenesis in the developing brain. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：103 / 108

页数：6

共 32 条

[1]

BALDWIN HS, 1994, DEVELOPMENT, V120, P2539

[2]

Blaschke AJ, 1996, DEVELOPMENT, V122, P1165

[3]

CHUN J, 2002, INT UNION PHARM, V34, P265

[4] THE RECOMBINATION ACTIVATING GENE-1 (RAG-1) TRANSCRIPT IS PRESENT IN THE MURINE CENTRAL-NERVOUS-SYSTEM [J].