Regulation of expression of methane monooxygenases by copper ions

被引:193
作者
Murrell, JC [1 ]
McDonald, IR [1 ]
Gilbert, B [1 ]
机构
[1] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
基金
英国生物技术与生命科学研究理事会; 英国自然环境研究理事会;
关键词
D O I
10.1016/S0966-842X(00)01739-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many methanotrophs contain both a soluble and a particulate methane monooxygenase. A unique metabolic switch, mediated by copper ions, regulates the expression of these enzymes. When the copper-to-biomass ratio of the cell is low, the soluble enzyme is expressed, and when the copper-to-biomass ratio is high, the particulate enzyme is expressed. A model for the mechanism of this switch is proposed.
引用
收藏
页码:221 / 225
页数:5
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