A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins

被引：46

作者：

Ranade, K

Hinds, D

Hsiung, CA

Chuang, LM

Chang, MS

Chen, YT

Pesich, R

Hebert, L

Chen, YDI

Dzau, V

Olshen, R

Curb, D

Botstein, D

Cox, DR

Risch, N

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA

[2] Natl Hlth Res Inst, Taipei, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[4] Taipei Vet Gen Hosp, Dept Internal Med, Taipei, Taiwan

[5] Taichung Vet Gen Hosp, Dept Internal Med, Taichung, Taiwan

[6] Stanford Univ, Sch Med, Div Endocrinol, Stanford, CA 94305 USA

[7] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[8] Hawaii Ctr Hlth Res, Honolulu, HI USA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2003年 / 16卷 / 02期

关键词：

hypertension; genetics; linkage;

D O I：

10.1016/S0895-7061(02)03245-4

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at similar to10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population. (C) 2003 American Journal of Hypertension, Ltd.

引用

页码：158 / 162

页数：5

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