Membrane and juxtamembrane targeting by PH and PTB domains

被引:128
作者
DiNitto, Jonathan P.
Lambright, David G.
机构
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
[2] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2006年 / 1761卷 / 08期
关键词
D O I
10.1016/j.bbalip.2006.04.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Modular pleckstrin homology (PH) and phospho-tyrosine binding (PTB) domains are present in a remarkably large number of proteins from yeast to humans. With a common core fold, these domain families have evolved to recognize membrane embedded phospholipids, in particular phosphoinositides, peripheral membrane proteins, and peptide motifs in juxtamembrane regions of integral membrane proteins. As the result of intensive investigation using biochemical, biophysical, and structural approaches, common ligand recognition principles have emerged along with insights into the structural variations that account for the diversity of ligand specificities. Analyses of membrane targeting in cells have revealed additional determinants beyond the primary ligand binding sites. In this review, we highlight unifying recognition principles and further illustrate with examples how divergent mechanisms contribute to membrane and juxtamembrane targeting by PH and PTB domains. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:850 / 867
页数:18
相关论文
共 159 条
[81]   PTEN and myotubularin: Novel phosphoinositide phosphatases [J].
Maehama, T ;
Taylor, GS ;
Dixon, JE .
ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :247-279
[82]   A PUTATIVE MODULAR DOMAIN PRESENT IN DIVERSE SIGNALING PROTEINS [J].
MAYER, BJ ;
REN, RB ;
CLARK, KL ;
BALTIMORE, D .
CELL, 1993, 73 (04) :629-630
[83]   Plasma membrane phosphoinositide organization by protein electrostatics [J].
McLaughlin, S ;
Murray, D .
NATURE, 2005, 438 (7068) :605-611
[84]   The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA - A model for discriminating proliferation and differentiation [J].
Meakin, SO ;
MacDonald, JIS ;
Gryz, EA ;
Kubu, CJ ;
Verdi, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (14) :9861-9870
[85]   Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons [J].
Meyer, D ;
Liu, A ;
Margolis, B .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (49) :35113-35118
[86]   The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery [J].
Mishra, SK ;
Watkins, SC ;
Traub, LM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (25) :16099-16104
[87]   Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 [J].
Morris, SM ;
Cooper, JA .
TRAFFIC, 2001, 2 (02) :111-123
[88]   THE PH DOMAIN - A COMMON PIECE IN THE STRUCTURAL PATCHWORK OF SIGNALING PROTEINS [J].
MUSACCHIO, A ;
GIBSON, T ;
RICE, P ;
THOMPSON, J ;
SARASTE, M .
TRENDS IN BIOCHEMICAL SCIENCES, 1993, 18 (09) :343-348
[89]   The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function [J].
Nagel, WG ;
Schilcher, P ;
Zeitlmann, L ;
Kolanus, W .
MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (08) :1981-1994
[90]   Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body [J].
Odorizzi, G ;
Babst, M ;
Emr, SD .
CELL, 1998, 95 (06) :847-858