Novel applications of the hypervalent iodine chemistry.: Synthesis of thiazolo-fused quinolinones

被引：10

作者：

Herrero, MT ^{[1
]}

Tellitu, I ^{[1
]}

Hernández, S ^{[1
]}

Domínguez, E ^{[1
]}

Moreno, I ^{[1
]}

SanMartín, R ^{[1
]}

机构：

[1] Univ Basque Country, Dept Quim Organ 2, Fac Ciencias, Euskal Herriko Unibertsitatea,Apdo 644, E-48080 Bilbao, Spain

来源：

ARKIVOC | 2002年

关键词：

hypervalent iodine; PIFA; HITB; quinoline; thiazole; cyclization;

D O I：

10.3998/ark.5550190.0003.505

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of thiazolo[5,4-c] quinolinone derivatives featuring the use of two different hypervalent iodine reagents has been achieved starting from ethyl benzoylacetate in an efficient way. Hydroxy(tosyloxy) phenyliodine (HITB, Koser's reagent) has been employed to functionalize the starting beta-ketoester 4, and phenyliodine(III) bis(trifluoroacetate) (PIFA) to perform a ring closure reaction on the corresponding N-methoxyamides 9 and 14.

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收藏

页码：A31 / +

页数：7

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