Advanced glycation endproducts stimulate the MAP-kinase pathway in tubulus cell line LLC-PK1

被引：77

作者：

Simm, A

Munch, G

Seif, F

Schenk, O

Heidland, A

Richter, H

Vamvakas, S

Schinzel, R

机构：

[1] UNIV WURZBURG,THEODOR BOVERI INST,D-97074 WURZBURG,GERMANY

[2] KURATORIUM DIALYSE & NIERENTRANSPLANTAT,D-97078 WURZBURG,GERMANY

[3] INST TOXIKOL,D-97078 WURZBURG,GERMANY

来源：

FEBS LETTERS | 1997年 / 410卷 / 2-3期

关键词：

advanced glycation endproducts; MAP-kinase; tubulus;

D O I：

10.1016/S0014-5793(97)00644-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advanced glycation endproducts (AGEs) are suggested to play an important role in diabetic nephropathy, They induce specific cellular responses such as the release of cytokines in different cell lines, The effect of AGEs on signal transduction pathways was investigated in the renal tubulus cell line LLC-PK1, Using a serine-phosphate-specific antibody AGE-induced cellular responses associated with phosphorylation/dephosphorylation events were demonstrated, In particular, the p42(MAP) kinase and its downstream target, the AP-I complex, are shown to be activated by AGE-BSA but not by BSA. In contrast, only partial phosphorylation is observed for the p70(S6)-kinase, Thus, AGEs appear to induce specific signal transduction pathways. (C) 1997 Federation of European Biochemical Societies.

引用

页码：481 / 484

页数：4

共 27 条

[1] EFFECTS OF MATRIX GLYCATION ON MESANGIAL CELL-ADHESION, SPREADING AND PROLIFERATION [J].