Lack of delayed effects of amphetamine, methoxamine, and prazosin (adrenergic drugs) on behavioral outcome after lateral fluid percussion brain injury in the rat

被引:6
作者
Dose, JM
Dhillon, HS
Maki, A
Kraemer, PJ
Prasad, RM
机构
[1] UNIV KENTUCKY,SCH MED,DEPT SURG,ALBERT B CHANDLER MED CTR,LEXINGTON,KY 40536
[2] UNIV KENTUCKY,SCH MED,DEPT PSYCHOL,ALBERT B CHANDLER MED CTR,LEXINGTON,KY 40536
关键词
fluid-percussion (FP) brain injury; norepinephrine; alpha 1-adrenergic receptor agonists and antagonists; behavioral deficits;
D O I
10.1089/neu.1997.14.327
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
This study examined the delayed effects of the administration of d-amphetamine, methoxamine (an alpha 1-adrenergic receptor agonist), and prazosin (an alpha 1-adrenergic receptor antagonist) on the behavioral outcome of lateral fluid-percussion (FP) brain injury. Rats trained to perform a beam-walking task were subjected to brain injury of moderate severity (2.1 to 2.2 atm). Twenty-four hours after injury, rats were treated with amphetamine, methoxamine, or prazosin at two or three different dose levels. Amphetamine-treated animals displayed no significant improvement in beam-walking ability either during or after drug intoxication (from days 3 to 5 after brain injury). Similarly, neither methoxamine nor prazosin significantly affected beam-walking ability during or after drug intoxication. Neither amphetamine treatment at three different doses nor treatment with methoxamine or prazosin at two different doses affected the spatial learning disabilities of brain-injured animals. These results suggest that (1) unlike amphetamine administration after sensorimotor cortex (SMC) ablation or contusion brain injury models, amphetamine administration at 24 h after concussive FP brain injury does not improve beam-walking performance; (2) unlike amphetamine administration 10 min after concussive FP brain injury amphetamine administration 24 h after injury does not improve cognitive function; and (3) unlike prazosin administration after SMC ablation brain injury, prazosin administration 24 h after concussive FP brain injury does not effect beam-walking performance.
引用
收藏
页码:327 / 337
页数:11
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