New cyclic peptide assemblies with hydrophobic cavities:: The structural and thermodynamic basis of a new class of peptide nanotubes

被引：184

作者：

Amorín, M

Castedo, L

Granja, JR ^{[1
]}

机构：

[1] Univ Santiago, Fac Quim, Dept Quim Organ, Santiago De Compostela 15782, Spain

[2] Univ Santiago, Fac Quim, CSIC, Unidade Asociado, Santiago De Compostela 15782, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 10期

关键词：

D O I：

10.1021/ja0296273

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new class of self-assembling peptides based on cyclic peptides made of alternating 3-aminocyclohexanecarboxylic acid (γ-Acc) and α-amino acids is described. The studied cylindrical assemblies are models for a new class of self-assembling peptide nanotubes (SPN) that present the particular property of having the C2 methylene group pointing toward the lumen of the cavity, modifying the properties of the inner surface of the assembly. Copyright © 2003 American Chemical Society.

引用

页码：2844 / 2845

页数：2

共 32 条

[1] Ajayan PM, 2001, TOP APPL PHYS, V80, P391
[2] Bong DT, 2001, ANGEW CHEM INT EDIT, V40, P988, DOI 10.1002/1521-3773(20010316)40:6<988::AID-ANIE9880>3.0.CO
[3] 2-N
[4] Bong DT, 2001, ANGEW CHEM INT EDIT, V40, P2163, DOI 10.1002/1521-3773(20010601)40:11<2163::AID-ANIE2163>3.0.CO
[5] 2-U
[6] Cylindrical β-sheet peptide assemblies
Clark, TD
Buriak, JM
Kobayashi, K
Isler, MP
McRee, DE
Ghadiri, MR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (35) : 8949 - 8962
[7] Self-assembling cyclic β3-peptide nanotubes as artificial transmembrane ion channels
Clark, TD
Buehler, LK
Ghadiri, MR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (04) : 651 - 656
[8] WIN SOME, LOSE SOME - ENTHALPY-ENTROPY COMPENSATION IN WEAK INTERMOLECULAR INTERACTIONS
DUNITZ, JD
[J]. CHEMISTRY & BIOLOGY, 1995, 2 (11): : 709 - 712
[9] STRUCTURE AND DYNAMICS OF SELF-ASSEMBLING PEPTIDE NANOTUBES AND THE CHANNEL-MEDIATED WATER ORGANIZATION AND SELF-DIFFUSION - A MOLECULAR-DYNAMICS STUDY
ENGELS, M
BASHFORD, D
GHADIRI, MR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (36) : 9151 - 9158
[10] Antibacterial agents based on the cyclic D,L-α-peptide architecture
Fernandez-Lopez, S
Kim, HS
Choi, EC
Delgado, M
Granja, JR
Khasanov, A
Kraehenbuehl, K
Long, G
Weinberger, DA
Wilcoxen, KM
Ghadiri, MR
[J]. NATURE, 2001, 412 (6845) : 452 - 455

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