New cyclic peptide assemblies with hydrophobic cavities:: The structural and thermodynamic basis of a new class of peptide nanotubes

被引：184

作者：

Amorín, M

Castedo, L

Granja, JR ^{[1
]}

机构：

[1] Univ Santiago, Fac Quim, Dept Quim Organ, Santiago De Compostela 15782, Spain

[2] Univ Santiago, Fac Quim, CSIC, Unidade Asociado, Santiago De Compostela 15782, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 10期

关键词：

D O I：

10.1021/ja0296273

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new class of self-assembling peptides based on cyclic peptides made of alternating 3-aminocyclohexanecarboxylic acid (γ-Acc) and α-amino acids is described. The studied cylindrical assemblies are models for a new class of self-assembling peptide nanotubes (SPN) that present the particular property of having the C2 methylene group pointing toward the lumen of the cavity, modifying the properties of the inner surface of the assembly. Copyright © 2003 American Chemical Society.

引用

页码：2844 / 2845

页数：2

共 32 条

[11] Gauthier D, 2001, ANGEW CHEM INT EDIT, V40, P4635, DOI 10.1002/1521-3773(20011217)40:24<4635::AID-ANIE4635>3.0.CO
[12] 2-D
[13] SELF-ASSEMBLING ORGANIC NANOTUBES BASED ON A CYCLIC PEPTIDE ARCHITECTURE
GHADIRI, MR
GRANJA, JR
MILLIGAN, RA
MCREE, DE
KHAZANOVICH, N
[J]. NATURE, 1993, 366 (6453) : 324 - 327
[14] THE STRUCTURAL AND THERMODYNAMIC BASIS FOR THE FORMATION OF SELF-ASSEMBLED PEPTIDE NANOTUBES
GHADIRI, MR
KOBAYASHI, K
GRANJA, JR
CHADHA, RK
MCREE, DE
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (01): : 93 - 95
[15] ARTIFICIAL TRANSMEMBRANE ION CHANNELS FROM SELF-ASSEMBLING PEPTIDE NANOTUBES
GHADIRI, MR
GRANJA, JR
BUEHLER, LK
[J]. NATURE, 1994, 369 (6478) : 301 - 304
[16] Insights on beta-hairpin stability in aqueous solution from peptides with enforced type I' and type II' beta-turns
Haque, TS
Gellman, SH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (09) : 2303 - 2304
[17] Self-assembling peptide nanotubes
Hartgerink, JD
Granja, JR
Milligan, RA
Ghadiri, MR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (01) : 43 - 50
[18] Molecular design and synthesis of artificial ion channels based on cyclic peptides containing unnatural amino acids
Ishida, H
Qi, Z
Sokabe, M
Donowaki, K
Inoue, Y
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (09) : 2978 - 2989
[19] NANOSCALE TUBULAR ENSEMBLES WITH SPECIFIED INTERNAL DIAMETERS - DESIGN OF A SELF-ASSEMBLED NANOTUBE WITH A 13-ANGSTROM PORE
KHAZANOVICH, N
GRANJA, JR
MCREE, DE
MILLIGAN, RA
GHADIRI, MR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (13) : 6011 - 6012
[20] BETA-SHEET PEPTIDE ARCHITECTURE - MEASURING THE RELATIVE STABILITY OF PARALLEL VS ANTIPARALLEL BETA-SHEETS
KOBAYASHI, K
GRANJA, JR
GHADIRI, MR
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (01): : 95 - 98

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