Role of p38 and JNK in liver ischemia and reperfusion

被引：64

作者：

King, LaShonda A. ^{[1
,2
]}

Toledo, Alexander H. ^{[3
]}

Rivera-Chavez, Fernando A. ^{[4
]}

Toledo-Pereyra, Luis H. ^{[1
,2
]}

机构：

[1] Michigan State Univ, Dept Res, Kalamazoo Ctr Med Studies, Kalamazoo, MI 49008 USA

[2] Michigan State Univ, Dept Surg, Kalamazoo Ctr Med Studies, Kalamazoo, MI 49008 USA

[3] Univ N Carolina, Div Abdominal Transplantat, Chapel Hill, NC USA

[4] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

来源：

JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY | 2009年 / 16卷 / 06期

关键词：

Liver ischemia; Reperfusion; p38; JNK; Ischemia mediators; ACTIVATED PROTEIN-KINASES; ATRIAL-NATRIURETIC-PEPTIDE; N-TERMINAL KINASE; RAT-LIVER; INJURY; PATHWAYS; TRANSPLANTATION; INHIBITION; APOPTOSIS; TARGETS;

D O I：

10.1007/s00534-009-0155-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The signal transduction of mitogen-activated protein kinases (MAPKs) has appeared to be an important mediator of ischemic-related events. Because of this, we analyzed the participation of p38 and JNK in liver ischemia and reperfusion, as two individual members of the MAPK family of proteins. All papers referred to in PubMed for the past 15 years were analyzed to determine how and when these MAPKs were considered to be an intricate part of the ischemic event. References were cross-studied to ascertain whether other papers could be found in the literature. The role of p38 and JNK in liver ischemia was confirmed in the literature. The activation of these mediators was associated with the induction of apoptosis and necrosis. Inhibitors of p38 and JNK reduced the liver ischemia and reperfusion damage, probably through the mechanisms mentioned before. The development of effective inhibitors of p38 and JNK protein mediators is important for minimizing the harmful effects associated with liver ischemia and reperfusion.

引用

页码：763 / 770

页数：8

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