Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53

被引:28
作者
Kimura, Y
Furuhata, T
Urano, T
Hirata, K
Nakamura, Y
Tokino, T
机构
[1] UNIV TOKYO,INST MED SCI,MOL MED LAB,MINTO KU,TOKYO 108,JAPAN
[2] SAPPORO MED UNIV,DEPT SURG 1,SAPPORO,HOKKAIDO 060,JAPAN
关键词
D O I
10.1006/geno.1997.4680
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Among its known functions, tumor suppressor gene p53 serves as a transcriptional regulator and mediates various signals through activation of downstream genes, We recently identified a novel gene, GML (glycosylphosphatidylinositol (GPI)-anchored molecule-like protein), whose expression is specifically induced by wildtype p53, To characterize the GML gene further, we determined 35.8 kb of DNA sequence that included a consensus binding sequence for p53 and the entire GML gene. The GML gene consists of four exons, and the p53-binding sequence is present in the 5'-flanking region. in genomic organization this gene resembles genes encoding murine Ly-6 glycoproteins, a human homologue of the Ly-6 family called RIG-E, and CD59; products of these genes, known as GPI-anchored proteins, are variously involved in signal transduction, cell-cell adhesion, and cell-matrix attachment. FISH analysis revealed that the GML gene is located on human chromosome 8q24.3. Genes encoding at least two other GPI-anchored molecules, E48 and RIG-E, are also located in this region. (C) 1997 Academic Press.
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收藏
页码:477 / 480
页数:4
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