Dynamic kinetic resolution-asymmetric transfer hydrogenation of 1-aryl-substituted cyclic ketones

被引：50

作者：

Alcock, NJ

Mann, I

Peach, P

Wills, M ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0957-4166(02)00648-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

A range of 1-aryl-2-tetranols, and 1-phenyl-2-indanol, have been generated in high yield and enantiomeric excess from the corresponding racemic ketones, via a dynamic kinetic resolution-transfer hydrogenation process, using Ru(II)-TsDPEN in formic acid/triethylamine (5:2). This provides a potential entry to an asymmetric total synthesis of benzazepines such as Sch 39166. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2485 / 2490

页数：6

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