Anatomical atlas-guided diffuse optical tomography of brain activation

被引：108

作者：

Custo, Anna ^{[1
,2
]}

Boas, David A. ^{[2
]}

Tsuzuki, Daisuke ^{[3
]}

Dan, Ippeita ^{[3
]}

Mesquita, Rickson ^{[2
,4
]}

Fischl, Bruce ^{[1
,2
]}

Grimson, W. Eric L. ^{[1
]}

Wells, Williams, III ^{[1
,5
]}

机构：

[1] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA

[3] Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan

[4] Univ Estadual Campinas, Inst Phys, BR-13083970 Campinas, SP, Brazil

[5] Harvard Univ, Sch Med, Brigham Womens Hosp, Boston, MA 02115 USA

来源：

NEUROIMAGE | 2010年 / 49卷 / 01期

关键词：

Diffuse optical tomography; NIRS; Anatomical atlas; MRI; Segmentation; Registration; Inverse problem; Human study; Somatosensory; NEAR-INFRARED SPECTROSCOPY; SURFACE-BASED ANALYSIS; MR-IMAGES; STIMULATION; CORTEX; REGISTRATION; ABSORPTION; MODELS; OXYGEN; FNIRS;

D O I：

10.1016/j.neuroimage.2009.07.033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We describe a neuroimaging protocol that utilizes an anatomical atlas of the human head to guide diffuse optical tomography of human brain activation. The protocol is demonstrated by imaging the hemodynamic response to median-nerve stimulation in three healthy subjects, and comparing the images obtained using a head atlas with the images obtained using the subject-specific head anatomy. The results indicate that using the head atlas anatomy it is possible to reconstruct the location of the brain activation to the expected gyrus of the brain, in agreement with the results obtained with the subject-specific head anatomy. The benefits of this novel method derive from eliminating the need for subject-specific head anatomy and thus obviating the need for a subject-specific MRI to improve the anatomical interpretation of diffuse optical tomography images of brain activation. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：561 / 567

页数：7

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