Chemo-enzymatic synthesis and functional analysis of natural and modified glycostructures

被引：13

作者：

Homann, Arne ^{[1
]}

Seibel, Juergen ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Organ Chem, D-97074 Wurzburg, Germany

来源：

NATURAL PRODUCT REPORTS | 2009年 / 26卷 / 12期

关键词：

BACILLUS-SUBTILIS LEVANSUCRASE; LACTIC-ACID BACTERIA; FREE CLICK CHEMISTRY; CARBOHYDRATE MICROARRAYS; LACTOBACILLUS-REUTERI; IN-VIVO; OLIGOSACCHARIDE SYNTHESIS; GLYCOPEPTIDE ANTIGENS; MUTANT GLYCOSIDASES; CRYSTAL-STRUCTURE;

D O I：

10.1039/b909990p

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The advancing field of glycomics is driven by the development of new analysis and synthesis techniques and novel strategies such as metabolic glyco-labeling. In this review we will present strategies for tailoring chemo-emzymatic glycosyltransfer reactions, screening methods such as carbohydrate-based micro-arrays, and metabolic glyco-engineering as a strategy to visualize biological recognition processes for the development of carbohydrate-based vaccines.

引用

页码：1555 / 1571

页数：17

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