Imagination and reality in the search for the P2Y receptors

被引：5

作者：

Barnard, EA ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England

来源：

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 2000年 / 81卷 / 1-3期

基金：

英国惠康基金;

关键词：

P2Y receptors; P2Y(1) receptor; recombinant; classification; density-dependent agonism;

D O I：

10.1016/S0165-1838(00)00147-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A great body of evidence based on tissue and organ physiology and pharmacology led to the recognition, widespread by about 1990, that there must be cell membrane receptors for extracellular nucleotides to transduce their effects. This evidence was provided by the pioneering work of Geoffrey Burnstock and those who worked with him, or was developed by others starting from that information. This article will review how we could start from that foundation to clone the first known gene for such a receptor, P2Y(1). Some unusual properties of that receptor were revealed. I will consider further the P2Y receptors as a class - its definition, now that many such genes have become known. Imagination and reality have been intertwined in this saga. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：10 / 15

页数：6

共 41 条

[31] Characterisation of a recombinant P-2Y purinoceptor [J].

Simon, J ;

Webb, TE ;

King, BF ;

Burnstock, G ;

Barnard, EA .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1995, 291 (03) :281-289

[32] ACTIVE MULTI-SUBUNIT ACH RECEPTOR ASSEMBLED BY TRANSLATION OF HETEROLOGOUS MESSENGER-RNA IN XENOPUS OOCYTES [J].

SUMIKAWA, K ;

HOUGHTON, M ;

EMTAGE, JS ;

RICHARDS, BM ;

BARNARD, EA .

NATURE, 1981, 292 (5826) :862-864

[33] The cytolytic P-2Z receptor for extracellular ATP identified as a P-2X receptor (P2X(7)) [J].

Surprenant, A ;

Rassendren, F ;

Kawashima, E ;

North, RA ;

Buell, G .

SCIENCE, 1996, 272 (5262) :735-738

[34] NEW CLASS OF LIGAND-GATED ION-CHANNEL DEFINED BY P-2X RECEPTOR FOR EXTRACELLULAR ATP [J].

VALERA, S ;

HUSSY, N ;

EVANS, RJ ;

ADAMI, N ;

NORTH, RA ;

SURPRENANT, A ;

BUELL, G .

NATURE, 1994, 371 (6497) :516-519

[35] Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation [J].

Wang, Y ;

Roman, R ;

Lidofsky, SD ;

Fitz, JG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :12020-12025

[36]

Webb TE, 1999, PROG BRAIN RES, V120, P23

[37] Identification of 6H1 as a P-2Y purinoceptor: P2Y(5) [J].

Webb, TE ;

Kaplan, MG ;

Barnard, EA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 219 (01) :105-110

[38] Regional distribution of [35S]2′-deoxy 5′-O-(1-thio) ATP binding sites and the P2Y1 messenger RNA within the chick brain [J].

Webb, TE ;

Simon, J ;

Barnard, EA .

NEUROSCIENCE, 1998, 84 (03) :825-837

[39] CLONING AND FUNCTIONAL EXPRESSION OF A BRAIN G-PROTEIN-COUPLED ATP RECEPTOR [J].

WEBB, TE ;

SIMON, J ;

KRISHEK, BJ ;

BATESON, AN ;

SMART, TG ;

KING, BF ;

BURNSTOCK, G ;

BARNARD, EA .

FEBS LETTERS, 1993, 324 (02) :219-225

[40]

Webb TE, 1998, J NEUROCHEM, V71, P1348

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