Asymmetric Mannich-type reactions of aldimines with a chiral acetate

被引：45

作者：

Saito, S ^{[1
]}

Hatanaka, K ^{[1
]}

Yamamoto, H ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, CREST, Japan Sci & Technol Corp, Nagoya, Aichi 4648603, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 13期

关键词：

D O I：

10.1021/ol000099e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We introduce here a strategy that enables effective addition of lithium enolates of acetates to aldimines. The new method depends strongly on the use of o-alkoxy (or o-fluoro) aniline-derived aldimines which have been found to have a potential effect on the enolate addition. This scope was expanded to the asymmetric process using the chiral acetate. A Lewis acid additive has a complementary role in the pronounced activation of imine functionalities.

引用

页码：1891 / 1894

页数：4

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