RETRACTED: A Type I-Secreted, Sulfated Peptide Triggers XA21-Mediated Innate Immunity (Retracted article. See vol. 342, pg. 191, 2013)

被引：190

作者：

Lee, Sang-Won ^{[1
]}

Han, Sang-Wook ^{[1
]}

Sririyanum, Malinee ^{[1
]}

Park, Chang-Jin ^{[1
]}

Seo, Young-Su ^{[1
]}

Ronald, Pamela C. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Plant Pathol, Davis, CA 95616 USA

来源：

SCIENCE | 2009年 / 326卷 / 5954期

关键词：

DISEASE RESISTANCE; GENE; FLAGELLIN; PERCEPTION; CAMPESTRIS; ACYLATION; ELICITOR; PATTERN; IMPACT; PLANTS;

D O I：

10.1126/science.1173438

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The rice Xa21 gene confers immunity to most strains of the bacterium Xanthomonas oryzae pv. oryzae (Xoo). Liquid chromatography-tandem mass spectrometry analysis of biologically active fractions from Xoo supernatants led to the identification of a 194-amino acid protein designated Ax21 (activator of XA21-mediated immunity). A sulfated, 17-amino acid synthetic peptide (axY(S)22) derived from the N-terminal region of Ax21 is sufficient for activity, whereas peptides lacking tyrosine sulfation are biologically inactive. Using coimmunoprecipitation, we found that XA21 is required for axY(S)22 binding and recognition. axY(S)22 is 100% conserved in all analyzed Xanthomonas species, confirming that Ax21 is a pathogen-associated molecular pattern and that XA21 is a pattern recognition receptor.

引用

页码：850 / 853

页数：4

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